MSH3 polyclonal, anti-human, mouse

Quantity: 100 µg

Background:
DNA mismatch repair protein, MutS Homolog 3 (MSH3), also known as MRP1 or DUP, is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. It is mapped to 5q14.1. The primary function of MSH3 is to maintain the stability of the genome and enact tumor suppression by forming the heterodimer MutSβ to correct long insertion/deletion loops and base-base mispairs. The most significant role of MSH3 in cancer is the suppression of tumors by repair of somatic mutations in DNA that occur as the result of base-base mispairs and insertion/deletion loops. Both loss of expression and over expression of MSH3 can leader tocarcinogenic effects. What’s more, it has been shown that inactivation of the MSH3 gene may be involved in the development of hematologic malignancies.

Description:
Rabbit IgG polyclonal antibody for DNA mismatch repair protein Msh3 (MSH3) detection. Tested with WB in Human, Mouse.

Synonyms:
Divergent upstream protein antibody, DNA mismatch repair protein antibody, DNA mismatch repair protein Msh 3 antibodyDNA mismatch repair protein Msh3 antibody, DUC 1 antibody, DUC1 antibody, DUG antibody, DUP antibody, hMSH3 antibody, MGC163306 antibody, MGC163308 antibody, Mismatch repair protein 1 antibody, MRP 1 antibody, MRP1 antibody, MSH 3 antibody, MSH3 antibody, MSH3_HUMAN antibody, MutS homolog 3 (E. coli) antibody, MutS homolog 3 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MSH3 recombinant protein (Position: E434-N739). Human MSH3 shares 83% amino acid (aa) sequence identity with mouse MSH3.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.