MSH4 polyclonal, anti-human, mouse

Background:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

Synonyms: hMSH4, MutS protein homolog 4

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human MSH4

Gene Symbol: MSH4

Gene ID: 4438

Swiss prot: O15457

Calculated MW: 105kDa

Recommended dilution:
IHC 1:100-300

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.