MSH4 Polyclonal Antibody

Background:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
hMSH4, MSH 4, MSH4, MSH4, MutS homolog 4 (E. Coli), MutS homolog 4, MutS protein homolog 4

Immunogen: Recombinant protein of human MSH4

Swissprot: O15457
Gene Accession: BC033030

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-69510/sc-69512