MSH6 antibody (clone 1F2), anti-human
€435.00
In stock
SKU
AC-AT2912a
Catalog Number: AC-AT2912a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
Request Information AC-AT2912a">Request Information
Background:
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
Other Names:
DNA mismatch repair protein Msh6, hMSH6, G/T mismatch-binding protein, GTBP, GTMBP, MutS-alpha 160 kDa subunit, p160, MSH6, GTBP
Antigen Type:
Recombinant Protein
Gene Name: MSH6 (HGNC:7329)
Gene ID: 2956
NCBI Accession: NP_000170.1
Primary Accession: P52701
Other Accession: NM_000179
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
Other Names:
DNA mismatch repair protein Msh6, hMSH6, G/T mismatch-binding protein, GTBP, GTMBP, MutS-alpha 160 kDa subunit, p160, MSH6, GTBP
Antigen Type:
Recombinant Protein
Gene Name: MSH6 (HGNC:7329)
Gene ID: 2956
NCBI Accession: NP_000170.1
Primary Accession: P52701
Other Accession: NM_000179
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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