MSH6 (clone 3A10H7), anti-human

MSH6 (clone 3A10H7), anti-human

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In stock
SKU
BT-MCA4287
Catalog Number: BT-MCA4287
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s):
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Background:
Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.

Research Area: Epigenetics and Nuclear Signaling

Synonyms: GTBP, HSAP, HNPCC5

Immunogen: Purified recombinant fragment of MSH6 expressed in E. Coli.

Formulation: Ascitic fluid containing 0.03% sodium azide.

Storage:
4°C|-20°C for long term storage
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