MSH6 polyclonal, anti-human antibody
€275.00
In stock
SKU
AC-ABV10676-100
Catalog Number: AC-ABV10676-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance.
Other Names:
MSH-6, MSH 6, DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTMBP, GTBP , mutS (E. coli) homolog 6, HNPCC 5, HNPCC5, MSH 6, MSH6
Primary Accession: P52701
Other Accession: NP_000170.1
Gene Name: MSH6 (HGNC:7329)
Gene ID: 2956
Concentration (mg/ml): 0.5 mg/ml
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance.
Other Names:
MSH-6, MSH 6, DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTMBP, GTBP , mutS (E. coli) homolog 6, HNPCC 5, HNPCC5, MSH 6, MSH6
Primary Accession: P52701
Other Accession: NP_000170.1
Gene Name: MSH6 (HGNC:7329)
Gene ID: 2956
Concentration (mg/ml): 0.5 mg/ml
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