MSH6 polyclonal, anti-human, mouse

Background:
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Synonyms: GTBP, HSAP, HNPCC5

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human MSH6

Gene Symbol: MSH6

Gene ID: 2956

Swiss prot: P52701

Calculated MW: 153kDa

Recommended dilution:
WB 1:200-1000, IHC 1:10-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.