MSH6 polyclonal, anti-human, mouse, monkey

Background:
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Synonyms: GTBP, GTMBP, HNPCC5, HSAP, p160

Cellular Location: Chromosome Nucleus

Immunogen:
Recombinant protein of human MSH6

Gene Symbol: MSH6

Gene ID: 2956

Swiss prot: P52701

Calculated MW: 153kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:20-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.