MSH6 polyclonal, anti-human, mouse, rat

Background:
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH6 heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world.

Alternative Name:
hMSH6, GTBP, GTMBP, p160, DNA mismatch repair protein Msh6, G/T mismatch binding protein, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC 5, HNPCC5, HSAP, MSH 6, MSH6, MSH6, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, MutS homolog 6 (E. coli), mutS homolog 6, MutS-alpha 160 kDa subunit, p160, Sperm associated protein,

Application Dilution:
WB:1:1,000
ICC:1:200
IHC:1:200
FC:1:100-1:200

Specificity: MSH6 polyclonal antibody detects endogenous levels of MSH6 protein.

Immunogen:
peptide

MW: 152 kDa

Swiss-Prot: P52701

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.