MSK1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Ribosomal protein S6 kinase alpha-5, also known as MSK1, is an enzyme that in humans is encoded by the RPS6KA5 gene. It belongs to the AGC family of kinases. MSK1 gene is mapped to chromosome 14q31-q32. Northern blot analysis indicated that MSK1 was expressed as a 4-kb mRNA in all tissues tested, with the highest levels of expression in brain, muscle, and placenta. MSK1 was activated in vitro and in vivo by either ERK or SAPK2 proteins. It has been found that MSK1, rather than MAPKAP-K1 or MAPKAP-K2/K3, mediates activation of the cAMP response element-binding protein and activating transcription factor-1 by either growth factors or stress signals.

Description:
Rabbit IgG polyclonal antibody for Ribosomal protein S6 kinase alpha-5 (RPS6KA5) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
90 kDa ribosomal protein S6 kinase 5 antibody, KS6A5_HUMAN antibody, MGC1911 antibody, Mitogen and stress activated protein kinase 1 antibody, MSPK1 antibody, Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody, Nuclear mitogen- and stress-activated protein kinase 1 antibody, Ribosomal protein S6 kinase 90kD polypeptide 5 antibody, Ribosomal protein S6 kinase 90kDa antibody, Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody, Ribosomal Protein S6 Kinase Alpha 5 antibody, Ribosomal protein S6 kinase alpha-5 antibody, RLPK antibody, RPS6KA5 antibody, RSK Like Protein Kinase antibody, RSK-like protein kinase antibody, RSKL antibody, S6K alpha 5 antibody, S6K-alpha-5 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MSK1 recombinant protein (Position: V540-Q665). Human MSK1 shares 98% amino acid (aa) sequence identity with mouse MSK1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.