MSR1 antibody (clone 2G8), anti-human
€435.00
In stock
SKU
AC-AT2919a
Catalog Number: AC-AT2919a
Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB, E
Request Information AC-AT2919a">Request Information
Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB, E
Request Information AC-AT2919a">Request Information
Background:
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Other Names:
Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1, SCARA1
Antigen Type:
Recombinant Protein
Gene Name: MSR1
Gene ID: 4481
NCBI Accession: NP_002436.1;NP_619729.1;NP_619730.1
Primary Accession: P21757
Other Accession: NM_138715
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Other Names:
Macrophage scavenger receptor types I and II, Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1, SCARA1
Antigen Type:
Recombinant Protein
Gene Name: MSR1
Gene ID: 4481
NCBI Accession: NP_002436.1;NP_619729.1;NP_619730.1
Primary Accession: P21757
Other Accession: NM_138715
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review