Mst2 polyclonal, anti-human, mouse, rat

Background:
Sterile-20 (Ste20) is a serine/threonine kinase in Saccharomyces cerevisiae that is involved in relaying signals from G protein-coupled receptors to cyto-solic MAP kinase cascades. Mammalian protein kinases that display sequence similarity to Ste20 are divided into two groups, the PAK subfamily and the GCK subfamily. The PAK subfamily members contain a C-terminal catalytic domain and an N-terminal regulatory domain with a p21Rac/Cdc42-binding site, and these kinases can activate both p38 MAPK and JNK. The GCK subfamily members contain a C-terminal regulatory domain and an N-terminal catalytic domain, and they have diverse roles in many pathways, including the activation of ERK, JNK, p38 MAPK, and caspase-3. The mammalian Ste20-like kinases (MST kinases), also known as Krs proteins, are members of the GCK subfamily. Ksr-1 (MST-2) and Ksr-2 (MST-1) are both direct substrates of caspase-3 that accelerate caspase-3 activation. MST-3 is ubiquitously expressed in mammalian tissue and can phosphorylate exogenous substrates as well as itself. MST-4 is highly expressed in placenta, thymus, and peripheral blood leukocytes, and it specifically activates ERK.

Alternative Name:
MST-2, STK3, KRS1, MST2, DKFZp686A2068, FLJ90748, KRS1, KRS2, Mammalian STE20 like protein kinase 1, Mammalian STE20 like protein kinase 2, MST 1, MST 2, MST1, MST2, Serine/threonine kinase 3 (STE20 homolog yeast), Serine/threonine kinase 3 (Ste20 yeast homolog), Serine/threonine kinase 3, Serine/threonine kinase 4, Serine/threonine protein kinase 3, Serine/threonine protein kinase 4, Serine/threonine protein kinase Krs 1, Serine/threonine protein kinase Krs 2, STE20 like kinase MST1, STE20 like kinase MST2, STK 3, STK 4, STK3, STK4, YSK3,

Application Dilution:
WB:1:1,000-1:5,000
IHC:1:50-1:200

Specificity: Mst2 polyclonal antibody detects endogenous levels of Mst2 protein.

Immunogen:
recombinant protein

MW: 36/56 kDa

Swiss-Prot: Q13188(Human) Q9JI11(Mouse) O54748(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.