MTA1 antibody (clone 4D5), anti-human, mouse, rat
€435.00
In stock
SKU
AC-AT2922a
Catalog Number: AC-AT2922a
Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB, IHChttps://www.abcepta.com/products/pdf_download/AT2922a-MTA1-Antibody-monoclonal-M01">Request Information AC-AT2922a">Request Information
Size: 100 µg
Isotype: mouse IgG3 Kappa
Applications: WB, IHChttps://www.abcepta.com/products/pdf_download/AT2922a-MTA1-Antibody-monoclonal-M01">Request Information AC-AT2922a">Request Information
Background:
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
Other Names:
Metastasis-associated protein MTA1, MTA1
Antigen Type:
Recombinant Protein
Gene Name: MTA1
Gene ID: 9112
NCBI Accession: NP_001190187.1;NP_004680.2
Primary Accession: Q13330
Other Accession: NM_004689
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
Other Names:
Metastasis-associated protein MTA1, MTA1
Antigen Type:
Recombinant Protein
Gene Name: MTA1
Gene ID: 9112
NCBI Accession: NP_001190187.1;NP_004680.2
Primary Accession: Q13330
Other Accession: NM_004689
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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