MTHFD1 polyclonal, anti-human

Background:
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.

Other Names:
C-1-tetrahydrofolate synthase, cytoplasmic, C1-THF synthase, Methylenetetrahydrofolate dehydrogenase, 1.5.1.5, Methenyltetrahydrofolate cyclohydrolase, 3.5.4.9, Formyltetrahydrofolate synthetase, 6.3.4.3, C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed, MTHFD1, MTHFC, MTHFD

Antigen Types:
Synthetic Peptide

Gene Name:
MTHFD1
Gene ID:
4522
Primary Accession: P11586
Other Accession: NP_005947;4522;108156 (mouse); 64300 (rat);