MTHFD1 Polyclonal Antibody

Background:
This gene encodes a protein that possesses three distinct enzymatic activities, 5, 10-methylenetetrahydrofolate dehydrogenase, 5, 10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.

Research Area: Cancer, Cell Biology, Metabolism, Signal Transduction

Synonyms:
MTHFD1, MTHFC, MTHFD

Immunogen: Recombinant fusion protein of human MTHFD1 (NP_005947.3).

Swissprot: P11586
Gene ID: 4522

Calculated MW: 101 kDa
Observed MW: 115 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:2000 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.