MTMR5 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6805a
Background:
The myotubularin (MTM) family constitutes one of the largest and most highly conserved protein-tyrosine phosphatase (PTP) subfamilies. Myotubularins, contain the consensus active site of tyrosine phosphatases but otherwise shows no homology to other phosphatases. PTP's usually act on substrates containing only phosphotyrosine sites, but myotubularins were shown to act on both phosphotyrosine and phosphoserine (dual specific). The enzymatic activity of myotubularins had not been demonstrated previously because it lacks catalytically active residues in tyrosine phosphatase/dual-specific phosphatase active site. The active site is however sufficiently preserved to bind phosphorylated substrates, and may protect from phosphatases. It was reported that interaction of myotubularin family members makes one of them catalytically active. MTMR5 can interact with MTMR2 and regulates the enzymatic activity and the subcellular localization of MTMR2. MTMR5 inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.Other suggested roles for MTMR5 are in spermatogenesis and germ cell differentiation. Binding partners for MTMR5 include the SET domain of MLL/HRX and SUV39H1.
Other Names:
Myotubularin-related protein 5, SET-binding factor 1, Sbf1, SBF1, MTMR5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6805a was selected from the C-term region of human MTMR5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SBF1
Gene ID: 6305
Primary Accession: O95248
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The myotubularin (MTM) family constitutes one of the largest and most highly conserved protein-tyrosine phosphatase (PTP) subfamilies. Myotubularins, contain the consensus active site of tyrosine phosphatases but otherwise shows no homology to other phosphatases. PTP's usually act on substrates containing only phosphotyrosine sites, but myotubularins were shown to act on both phosphotyrosine and phosphoserine (dual specific). The enzymatic activity of myotubularins had not been demonstrated previously because it lacks catalytically active residues in tyrosine phosphatase/dual-specific phosphatase active site. The active site is however sufficiently preserved to bind phosphorylated substrates, and may protect from phosphatases. It was reported that interaction of myotubularin family members makes one of them catalytically active. MTMR5 can interact with MTMR2 and regulates the enzymatic activity and the subcellular localization of MTMR2. MTMR5 inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.Other suggested roles for MTMR5 are in spermatogenesis and germ cell differentiation. Binding partners for MTMR5 include the SET domain of MLL/HRX and SUV39H1.
Other Names:
Myotubularin-related protein 5, SET-binding factor 1, Sbf1, SBF1, MTMR5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6805a was selected from the C-term region of human MTMR5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: SBF1
Gene ID: 6305
Primary Accession: O95248
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review