MTMR6 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6806a
Background:
The myotubularin (MTM) family constitutes one of the largest and most highly conserved protein-tyrosine phosphatase (PTP) subfamilies. Myotubularins, contain the consensus active site of tyrosine phosphatases but otherwise shows no homology to other phosphatases. PTP's usually act on substrates containing only phosphotyrosine sites, but myotubularins were shown to act on both phosphotyrosine and phosphoserine (dual specific). The enzymatic activity of myotubularins had not been demonstrated previously because it lacks catalytically active residues in tyrosine phosphatase/dual-specific phosphatase active site. The active site is however sufficiently preserved to bind phosphorylated substrates, and may protect from phosphatases. It was reported that interaction of myotubularin family members makes one of them catalytically active. The 4.8-kb MTMR6 mRNA is expressed ubiquitously. By analysis of radiation and somatic cell hybrids, the MTMR6 gene has been mapped to 13q12. MTMR6 corresponds to an EST located within a cloned region that encompasses a translocation breakpoint t(8;13) observed in 2 patients with an atypical myoproliferative disorder.
Other Names:
Myotubularin-related protein 6, 313-, MTMR6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6806a was selected from the C-term region of human MTMR6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MTMR6 (HGNC:7453)
Gene ID: 9107
Primary Accession: Q9Y217
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The myotubularin (MTM) family constitutes one of the largest and most highly conserved protein-tyrosine phosphatase (PTP) subfamilies. Myotubularins, contain the consensus active site of tyrosine phosphatases but otherwise shows no homology to other phosphatases. PTP's usually act on substrates containing only phosphotyrosine sites, but myotubularins were shown to act on both phosphotyrosine and phosphoserine (dual specific). The enzymatic activity of myotubularins had not been demonstrated previously because it lacks catalytically active residues in tyrosine phosphatase/dual-specific phosphatase active site. The active site is however sufficiently preserved to bind phosphorylated substrates, and may protect from phosphatases. It was reported that interaction of myotubularin family members makes one of them catalytically active. The 4.8-kb MTMR6 mRNA is expressed ubiquitously. By analysis of radiation and somatic cell hybrids, the MTMR6 gene has been mapped to 13q12. MTMR6 corresponds to an EST located within a cloned region that encompasses a translocation breakpoint t(8;13) observed in 2 patients with an atypical myoproliferative disorder.
Other Names:
Myotubularin-related protein 6, 313-, MTMR6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6806a was selected from the C-term region of human MTMR6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MTMR6 (HGNC:7453)
Gene ID: 9107
Primary Accession: Q9Y217
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review