MTNR1A polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60605
Background:
Melatonin (Mel), a hormone secreted by the pineal gland, is expressed at night in response to the circadian clock . Melatonin is thought to be involved in regulating reproductive physiological development and the progression of sexual maturation, and it is also thought to play a role in tumorigenesis . The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. Signaling through the melatonin receptors inhibits adenylate cyclase and stimulates phospholipase Cb upon activation of pertussis toxin (PTX)-sensitive G proteins. MEL-1A-R may be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin .
Alternative Name:
Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A
Application Dilution: WB: 1:500~1:1000
Specificity: MTNR1A polyclonal antibody detects endogenous levels of MTNR1A protein.
Immunogen:
A synthetic peptide corresponding to residues in Human MTNR1A
MW: ~ 39 kDa
Swis Prot.: P48039
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Melatonin (Mel), a hormone secreted by the pineal gland, is expressed at night in response to the circadian clock . Melatonin is thought to be involved in regulating reproductive physiological development and the progression of sexual maturation, and it is also thought to play a role in tumorigenesis . The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. Signaling through the melatonin receptors inhibits adenylate cyclase and stimulates phospholipase Cb upon activation of pertussis toxin (PTX)-sensitive G proteins. MEL-1A-R may be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin .
Alternative Name:
Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A
Application Dilution: WB: 1:500~1:1000
Specificity: MTNR1A polyclonal antibody detects endogenous levels of MTNR1A protein.
Immunogen:
A synthetic peptide corresponding to residues in Human MTNR1A
MW: ~ 39 kDa
Swis Prot.: P48039
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review