mTOR (phospho-T2446) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4598
Background:
mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Alternative Name:
Centrosomal protein of 70 kDa, Cep70, p10-binding protein, CEP70, BITE
Application Dilution: WB: 1:500~1:1000
Specificity: p-mTOR (T2446) pAb detects endogenous levels of mTOR protein only when phosphorylated at Thr2446.
Immunogen:
Synthetic peptide, corresponding to amino acids 246-306 of Human CEP70.
MW: ~ 289 kDa
Swis Prot.: P42345
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Alternative Name:
Centrosomal protein of 70 kDa, Cep70, p10-binding protein, CEP70, BITE
Application Dilution: WB: 1:500~1:1000
Specificity: p-mTOR (T2446) pAb detects endogenous levels of mTOR protein only when phosphorylated at Thr2446.
Immunogen:
Synthetic peptide, corresponding to amino acids 246-306 of Human CEP70.
MW: ~ 289 kDa
Swis Prot.: P42345
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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