mTOR polyclonal, anti-human, mouse, rat antibody
€310.00
In stock
SKU
AC-ABV10606-100
Catalog Number: AC-ABV10606-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.
Other Names:
FRAP1, FK506 binding protein 12-rapamycin associated protein 1, FRAP2, FK506 binding protein 12-rapamycin associated protein 2, RAFT1, RAPT1
Primary Accession: P42345
Other Accession: NP_004949.1
Gene Name: MTOR
Gene ID: 2475
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.
Other Names:
FRAP1, FK506 binding protein 12-rapamycin associated protein 1, FRAP2, FK506 binding protein 12-rapamycin associated protein 2, RAFT1, RAPT1
Primary Accession: P42345
Other Accession: NP_004949.1
Gene Name: MTOR
Gene ID: 2475
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