MTR-1A polyclonal, anti-human, mouse, rat, sheep, bovine

Protein Family: Receptors and Channels

Pathway and Disease: Signaling Molecules and Interaction

Description:
Melatonin receptor-1A (MTR-1A) is a high affinity receptor for melatonin, which mediates the reproductive and circadian actions of melatonin. MTR-1A activity is mediated by pertussis toxin sensitive G-proteins that inhibit adenylate cyclase activity. MTR-1A is expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). MTR-1A belongs to the G-protein coupled receptor 1 family.

Alternate Names: Melatonin receptor type 1A, Mel1a melatonin receptor, Mel-1A-R, MTNR1A, MTR1A

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P48039

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MTR-1A.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
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[2] Wang S et al. 2012. Pain. 153(120): 2448-57. PMID 23046768.
[3] Peliciari-Garcia R et al. 2011. Chronobiology International. 28(1): 21-30. PMID 21182401.
[4] Ahn S et al. 2011. Auris nasus Larynx. 39(5): 479-483. PMID 22055508.
[5] Corthell JT. et al. 2013. Neuroscience. PMID 24365461.
[6] Huang F et al. 2013. Neural Regeneration Research. 8(32): 2991-3002.