MUC1 (clone VU-3C6), anti-human

Source:
A BALB/c mouse was immunized with ZR-75-1 breast cancer cells.
Fusion partner: SP2/0.

Specifications:
VU-3C6 reacts with the protein core of MUC1, an apical cell side epithelial marker which is upregulated or switched on in the majority of carcinomas. The dominant epitope of VU-3-C6 is GVTSAPDTRPAP, located in the VNTR domain of MUC1. Binding of VU-3C6 is enhanced after glycosylation of the DTR motif. VU-3C6 was typed at the ISOBM TD-4 workshop.

Species reactivity:
Positive: human.

Applications:
VU-3C6 can be used for immunohistochemistry, ELISA and fluorescence tests.
ELISA: +
Frozen sections: +
Immunofluorescence: +
Paraffin sections: Periodic acid

Positive control: MCF-7 or MDA-231 cells. Breast, colon, ovarian, endometrial carcinoma.

References:
- ISOBM TD-4 Workshop report, Tumor Biol.19(Suppl 1) (1998).Karsten, U. et al. Cancer. Res. 58(12): 2541-2549 (1998).Ryuko, K. et al. Tumor Biol.21(4): 197-210 (2000)