MUC2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Mucin 2, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. This gene encodes a member of the mucin protein family. It is mapped to 11p15.5. Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium. The primary function of the MUC2 gene product is to provide a protective barrier between the epithelial surfaces and the gut lumen. There is decreased expression of MUC2 in colonic cancer and defective polymerization of secreted mucin in ulcerative colitis.

Description:
Rabbit IgG polyclonal antibody for Mucin-2 (MUC2) detection. Tested with IHC-P in Human, Mouse, Rat.

Synonyms:
Intestinal mucin 2 antibody, Intestinal mucin-2 antibody, MLP antibody, MUC 2 antibody, MUC-2 antibody, Muc2 antibody, MUC2_HUMAN antibody, Mucin 2 antibody, Mucin 2 intestinal antibody, Mucin 2 intestinal/tracheal antibody, Mucin 2 oligomeric mucus/gel forming antibody, Mucin 2 precursor antibody, Mucin 2 tracheal antibody, Mucin like protein antibody, Mucin-2 antibody, Mucin2 antibody, SMUC antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MUC2 recombinant protein (Position: S21-W380). Human MUC2 shares 78% and 79% amino acid (aa) sequences identity with mouse and rat MUC2, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.