Muscarinic Acetylcholine Receptor 2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor. The M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after stimulatory actions of the sympathetic nervous system, by slowing the speed of depolarization. The CHRM2 gene inhibits the release of acetylcholine from cholinergic fibers in the lungs and elsewhere. In airway parasympathetic neurons, it is decreased by viral infections and by interferon-gamma, increasing actylcholine release. This gene is though to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing. In a sample of 667 individuals from 304 families, Gosso MF et al. genotyped three single-nucleotide polymorphisms(SNPs) in the CHRM2 gene on 7q31-35. CHRM2 is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2(CHRM2) gene with alcohol dependence and major depressive syndrome.

Description:
Rabbit IgG polyclonal antibody for Muscarinic acetylcholine receptor M2 (CHRM2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
7TM receptor antibody, Acetylcholine receptor, muscarinic, 2 antibody, Acm2 antibody, ACM2_HUMAN antibody, Cholinergic receptor muscarinic 2 antibody, Cholinergic receptor, muscarinic 2, cardiac antibody, Cholinergic receptor, muscarinic 2, isoform a antibody, Cholinergic receptor, muscarinic 2a antibody, CHRM 2 antibody, CHRM2 antibody, chrm2a antibody, CM2 antibody, FLJ43243 antibody, HM 2 antibody, HM2 antibody, M2 antibody, M2 muscarinic receptor antibody, MGC120006 antibody, MGC120007 antibody, Muscarinic acetylcholine receptor M2 antibody, Muscarinic M2 receptor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Muscarinic Acetylcholine Receptor 2(356-370aa EKQNIVARKIVKMTK), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Muscarinic Acetylcholine Receptor 2(356-370aa EKQNIVARKIVKMTK), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.