MUTYH Polyclonal Antibody

Background:
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
A/G specific adenine DNA glycosylase, A/G-specific adenine DNA glycosylase, Adenine DNA glycosylase, CYP2C, hMYH, MGC4416, MutY (E. coli) homolog, MutY homolog (E. coli), MutY homolog, MutY, E. coli, homolog of, Mutyh, MUTYH, MYH, rMYH

Immunogen: Recombinant protein of human MUTYH

Swissprot: Q9UIF7
Gene Accession: BC003178

Calculated MW: 60 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-25169/sc-25171/sc-30630/sc-99211