MVP polyclonal, anti-human, mouse, rat

Background:
Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less, contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.

Alternative Name:
MVP, LRP, LRP, Lung resistance related protein, Lung resistance-related protein, Major vault protein, Major vault protein, rat, homolog of, MVP, MVP, testicular secretory protein Li 30, VAULT 1, VAULT1,

Application Dilution:
WB:1:500-1:1,000
IHC:1:50-1:200

Specificity: MVP polyclonal antibody detects endogenous levels of MVP protein.

Immunogen:
Recombinant protein

MW: 99 kDa

Swiss-Prot: Q14764(Human) Q9EQK5(Mouse) Q62667(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.