MX2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5805
Background:
Members of the Dynamin family include GTPase, microtubule-associated proteins that are involved in cellular trafficking, including microtubule bundling and endocytosis. Mx1, also known as MxA, an interferon (IFN)-induced protein, acquires a high degree of resistance to influenza A virus and the rhabdo-virus vesicular stomatitis virus (VSV), which suggests that Mx1 plays an active role against influenza virus and the rhabdovirus VSV. Mx1 is a cytoplasmic protein that is 63% identical to the Mx2 protein, which lacks antiviral activity. Mx2 is also known as MxB and is localized at the cytoplasmic face of nuclear pores. Mx2 expression is not interferon-dependent and this protein is thought to regulate the efficiency and/or kinetics of nuclear import, a function which may have been usurped by its antiviral relatives.
Alternative Name:
Interferon-induced GTP-binding protein Mx2, Interferon-regulated resistance GTP-binding, protein MxB, Myxovirus resistance protein 2, p78-related protein
Application Dilution: WB: 1:500~1:1000
Specificity: MX2 polyclonal antibody detects endogenous levels of MX2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 414-459 of Human MX2.
MW: ~ 82 kDa
Swis Prot.: P20592
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Members of the Dynamin family include GTPase, microtubule-associated proteins that are involved in cellular trafficking, including microtubule bundling and endocytosis. Mx1, also known as MxA, an interferon (IFN)-induced protein, acquires a high degree of resistance to influenza A virus and the rhabdo-virus vesicular stomatitis virus (VSV), which suggests that Mx1 plays an active role against influenza virus and the rhabdovirus VSV. Mx1 is a cytoplasmic protein that is 63% identical to the Mx2 protein, which lacks antiviral activity. Mx2 is also known as MxB and is localized at the cytoplasmic face of nuclear pores. Mx2 expression is not interferon-dependent and this protein is thought to regulate the efficiency and/or kinetics of nuclear import, a function which may have been usurped by its antiviral relatives.
Alternative Name:
Interferon-induced GTP-binding protein Mx2, Interferon-regulated resistance GTP-binding, protein MxB, Myxovirus resistance protein 2, p78-related protein
Application Dilution: WB: 1:500~1:1000
Specificity: MX2 polyclonal antibody detects endogenous levels of MX2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 414-459 of Human MX2.
MW: ~ 82 kDa
Swis Prot.: P20592
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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