MXI1 polyclonal (Center), anti-human, mouse
€0.00
In stock
SKU
AC-AP14974c
Catalog Number: AC-AP14974c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34949
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34949
Applications: WB
Datasheet
Request Information
Background:
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Other Names:
Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11
Target/Specificity:
This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1.
Antigen Region:
53-82
Antigen Type: Synthetic Peptide
Gene Name: MXI1
Gene ID: 4601
Primary Accession: P50539
NCBI Accession: NP_001008541.1;NP_005953.4;NP_569157.2
Other Accession: O09015; P50540; NP_005953.4; NP_569157.2; NP_001008541.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.
Other Names:
Max-interacting protein 1, Max interactor 1, Class C basic helix-loop-helix protein 11, bHLHc11, MXI1, BHLHC11
Target/Specificity:
This MXI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the Central region of human MXI1.
Antigen Region:
53-82
Antigen Type: Synthetic Peptide
Gene Name: MXI1
Gene ID: 4601
Primary Accession: P50539
NCBI Accession: NP_001008541.1;NP_005953.4;NP_569157.2
Other Accession: O09015; P50540; NP_005953.4; NP_569157.2; NP_001008541.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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