Myb Sumoylation Site polyclonal, anti-mouse
€0.00
In stock
SKU
AC-AP2500a
Catalog Number: AC-AP2500a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2559
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2559
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.
Other Names:
Transcriptional activator Myb, Proto-oncogene c-Myb, MYB
Target/Specificity:
This Myb Sumoylation Site antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from human Myb Sumoylation Site.
Antigen Region:
506-534
Antigen Type: Synthetic Peptide
Gene Name: MYB
Gene ID: 4602
Primary Accession: P10242
NCBI Accession: NP_001123644.1;NP_001123645.1;NP_001155128.1;NP_001155129.1;NP_001155130.1;NP_001155131.1;NP_001155132.1;NP_005366.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.
Other Names:
Transcriptional activator Myb, Proto-oncogene c-Myb, MYB
Target/Specificity:
This Myb Sumoylation Site antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from human Myb Sumoylation Site.
Antigen Region:
506-534
Antigen Type: Synthetic Peptide
Gene Name: MYB
Gene ID: 4602
Primary Accession: P10242
NCBI Accession: NP_001123644.1;NP_001123645.1;NP_001155128.1;NP_001155129.1;NP_001155130.1;NP_001155131.1;NP_001155132.1;NP_005366.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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