MYBPC3 polyclonal, anti-rat

Background:
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

Alternative Name:
FHC, CMH4, CMD1MM, LVNC10, MYBP-C

Application Dilution: WB: 1:500 - 1:2000

Specificity: MYBPC3 polyclonal antibody detects endogenous levels of MYBPC3 protein.

Immunogen:
Recombinant protein of human MYBPC3

MW: Predicted band size: 141 kDa, Observed band size: Refer to Figures

Swis Prot.: Q14896

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.