Myc (phospho-T358) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4127
Background:
c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function.
Alternative Name:
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IP: 1:50~1:200
Specificity: p-Myc (T358) polyclonal antibody detects endogenous levels of proto-oncogene c-Myc protein only when phosphorylated at Thr358.
Immunogen:
Synthetic phosphopeptide derived from human Myc around the phosphorylation site of Threonine 358.
MW: ~ 49, 57, 65 kDa
Swis Prot.: P01106
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function.
Alternative Name:
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IP: 1:50~1:200
Specificity: p-Myc (T358) polyclonal antibody detects endogenous levels of proto-oncogene c-Myc protein only when phosphorylated at Thr358.
Immunogen:
Synthetic phosphopeptide derived from human Myc around the phosphorylation site of Threonine 358.
MW: ~ 49, 57, 65 kDa
Swis Prot.: P01106
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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