MyD88 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
MYD88(MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88), is a protein that, in humans, is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors(TLRs) and interleukin-1 receptors(IL1Rs). And it is mapped on 3p22.2. MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. Qverexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.

Description:
Rabbit IgG polyclonal antibody for Myeloid differentiation primary response protein MyD88 (MYD88) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
MYD 88 antibody, Myd88 antibody, MYD88_HUMAN antibody, MYD88D antibody, Myeloid differentiation marker 88 antibody, Myeloid differentiation primary response gene 88 antibody, Myeloid differentiation primary response gene antibody, Myeloid differentiation primary response protein MyD88 antibody, OTTHUMP00000161718 antibody, OTTHUMP00000208595 antibody, OTTHUMP00000209058 antibody, OTTHUMP00000209059 antibody, OTTHUMP00000209060 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human MyD88(174-188aa FVQEMIRQLEQTNYR), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence in the middle region of human MyD88(174-188aa FVQEMIRQLEQTNYR), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.