MYD88 Polyclonal Antibody

Background:
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction

Synonyms:
MYD88, MYD88D, myeloid differentiation primary response 88, MyD88

Immunogen: Recombinant fusion protein of human MYD88 (NP_002459.2).

Swissprot: Q99836
Gene ID: 4615

Calculated MW: 15 kDa/20 kDa/28 kDa/31 kDa/33 kDa/34 kDa
Observed MW: 37 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.