Myelin P0 Protein polyclonal, anti-human, mouse, rat, bovine, pig, horse

Protein Family: CAM Ligands, Cell Adhesion Molecules

Pathway and Disease: Signaling Molecules and Interaction

Description:
The Myelin P0 protein (MPZ) creates an extracellular membrane face to guide the wrapping process for ultimately compacting adjacent lamellae. MPZ is a single-pass type I membrane protein only found in peripheral nervous system Schwann cells. Defects in MPZ are the cause of Charcot-Marie-Tooth disease, an inherited peripheral nervous system disorder characterized by muscle and nerve atrophy.

Alternate Names: Myelin P0 protein, Myelin protein zero, Myelin peripheral protein, MPP, MPZ

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P25189

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human myelin P0 protein.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Yoshimura K et al. 2011. Elsevier. Differentiation. 83(2):S78-S85. PMID# 22101064.