MYH7 Polyclonal Antibody

Background:
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Research Area: Cancer, Cardiovascular, Developmental Biology, Signal Transduction, Stem Cells

Synonyms:
MYH7, CMD1S, CMH1, MPD1, MYHCB, SPMD, SPMM, myosin-7, MYH7

Immunogen: Recombinant fusion protein of human MYH7 (NP_000248.2).

Swissprot: P12883
Gene ID: 4625

Calculated MW: 223 kDa
Observed MW: 223 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.