MYLIP polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61709
Background:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Alternative Name:
E3 ubiquitin-protein ligase MYLIP, Inducible degrader of the LDL-receptor, Idol, Myosin regulatory light chain interacting protein, MIR, RING-type E3 ubiquitin transferase MYLIP, MYLIP, BZF1, IDOL, BM-023, PP5242
Application Dilution: WB: 1:500~1:1000
Specificity: MYLIP polyclonal antibody detects endogenous levels of MYLIP protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 150-200 of Human MYLIP.
MW: ~ 49 kDa
Swis Prot.: Q8WY64
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Alternative Name:
E3 ubiquitin-protein ligase MYLIP, Inducible degrader of the LDL-receptor, Idol, Myosin regulatory light chain interacting protein, MIR, RING-type E3 ubiquitin transferase MYLIP, MYLIP, BZF1, IDOL, BM-023, PP5242
Application Dilution: WB: 1:500~1:1000
Specificity: MYLIP polyclonal antibody detects endogenous levels of MYLIP protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 150-200 of Human MYLIP.
MW: ~ 49 kDa
Swis Prot.: Q8WY64
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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