MYOF Polyclonal Antibody

Background:
Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.

Research Area: Cancer, Cell Biology, Cardiovascular

Synonyms:
MYOF, FER1L3, myoferlin

Immunogen: Recombinant fusion protein of human MYOF (NP_038479.1).

Swissprot: Q9NZM1
Gene ID: 26509

Calculated MW: 17 kDa/46 kDa/49 kDa/179 kDa/229 kDa/233 kDa/234 kDa
Observed MW: 250 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.