Myogenin (Skeletal Muscle Marker) (clone SPM144 ), anti-human, mouse, rat, cat, pig
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In stock
SKU
AC-AH10623
Catalog Number: AC-AH10623
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM144
Applications: WB, IHC-P, IF, FC, E, IP
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM144
Applications: WB, IHC-P, IF, FC, E, IP
Datasheet
Request Information
Background:
Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms� tumor.
Other Names:
Myogenin, Class C basic helix-loop-helix protein 3, bHLHc3, Myogenic factor 4, Myf-4, MYOG, BHLHC3, MYF4
Gene Name: MYOG
Gene ID: 4656
Primary Accession: P15173
Other Accession: 4656, 2830
Myogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms� tumor.
Other Names:
Myogenin, Class C basic helix-loop-helix protein 3, bHLHc3, Myogenic factor 4, Myf-4, MYOG, BHLHC3, MYF4
Gene Name: MYOG
Gene ID: 4656
Primary Accession: P15173
Other Accession: 4656, 2830
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