MYOM1 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13444c
Background:
The giant protein titin, together with its associatedproteins, interconnects the major structure of sarcomeres, the Mbands and Z discs. The C-terminal end of the titin string extendsinto the M line, where it binds tightly to M-band constituents ofapparent molecular masses of 190 kD (myomesin 1) and 165 kD(myomesin 2). This protein, myomesin 1, like myomesin 2, titin, andother myofibrillar proteins contains structural modules with stronghomology to either fibronectin type III (motif I) or immunoglobulinC2 (motif II) domains. Myomesin 1 and myomesin 2 each have a uniqueN-terminal region followed by 12 modules of motif I or motif II, inthe arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteinsshare 50% sequence identity in this repeat-containing region. Thehead structure formed by these 2 proteins on one end of the titinstring extends into the center of the M band. The integratingstructure of the sarcomere arises from muscle-specific members ofthe superfamily of immunoglobulin-like proteins. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.
Other Names:
Myomesin-1, 190 kDa connectin-associated protein, 190 kDa titin-associated protein, Myomesin family member 1, MYOM1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13444c was selected from the Center region of MYOM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MYOM1
Gene ID: 8736
Primary Accession: P52179
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The giant protein titin, together with its associatedproteins, interconnects the major structure of sarcomeres, the Mbands and Z discs. The C-terminal end of the titin string extendsinto the M line, where it binds tightly to M-band constituents ofapparent molecular masses of 190 kD (myomesin 1) and 165 kD(myomesin 2). This protein, myomesin 1, like myomesin 2, titin, andother myofibrillar proteins contains structural modules with stronghomology to either fibronectin type III (motif I) or immunoglobulinC2 (motif II) domains. Myomesin 1 and myomesin 2 each have a uniqueN-terminal region followed by 12 modules of motif I or motif II, inthe arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteinsshare 50% sequence identity in this repeat-containing region. Thehead structure formed by these 2 proteins on one end of the titinstring extends into the center of the M band. The integratingstructure of the sarcomere arises from muscle-specific members ofthe superfamily of immunoglobulin-like proteins. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.
Other Names:
Myomesin-1, 190 kDa connectin-associated protein, 190 kDa titin-associated protein, Myomesin family member 1, MYOM1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13444c was selected from the Center region of MYOM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MYOM1
Gene ID: 8736
Primary Accession: P52179
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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