Myosin-11 polyclonal, anti-human, rat

Background:
Myosin is a highly conserved, ubiquitously expressed protein that interacts with Actin to generate the force for cellular movements. Conventional Myosins are hexameric proteins consisting of two heavy chain subunits, a pair of non-phosphorylatable light chain subunits and a pair of phosphorylatable light chain subunits, which is expressed by my calcium and calmodulin-dependent phosphorylation of Myosin light chain (MLC) Myosin heavy chains, encoded by the MYH gene family, contain Actin-activated ATPase activity which generates the motor function of Myosin. Myosin heavy chains were initially isolated from a human fetal skeletal muscle and are the major determinant in the Speed of contraction of skeletal muscle. Various isoforms of myosin heavy chains are differentially expressed depending on th E functional activity of the muscle.

Alternative Name:
MYH11, KIAA0866, AAT4, DKFZp686D10126, DKFZp686D19237, FAA4, FLJ35232, MGC126726, MGC32963, MYH 11, MYH11, MYH11, Myosin 11, Myosin heavy chain 11, Myosin heavy chain 11 smooth muscle, Myosin heavy chain, Myosin heavy chain smooth muscle isoform, Myosin heavy polypeptide 11 smooth muscle, Myosin-11, SMHC, SMMHC, smooth muscle isoform, Smooth muscle myosin heavy chain 11 isoform SM2, Smooth muscle myosin heavy chain isoform SM2,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Myosin-11 polyclonal antibody detects endogenous levels of Myosin-11 protein.

Immunogen:
recombinant protein

MW: 227 kDa

Swiss-Prot: P35749(Human) Q63862(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.