Myosin 4/MyHC-IIB (C-terminus) Blocking Peptide
€155.00
In stock
SKU
ECM-MX4545
Background:
Myosin is a highly conserved, ubiquitous protein found in all eukaryotic cells, where it provides the motor function for diverse movements such as cytokinesis, phagocytosis, and muscle contraction. All myosins contain an amino-terminal motor/head domain and a carboxy-terminal tail domain. The class II myosins, consist of the conventional two-headed myosins that form filaments and are composed of two myosin heavy chain (MYH) subunits and four myosin light chain subunits. There are 15 MYH genes identified as Class II myosins and these include six skeletal muscle MYHs (MYH1, MYH2, MYH3, MYH4, MYH8, MYH13), three cardiac MYHs (MYH6, MYH7, MYH7B) and two non-muscle MYHs (MYH9, MYH10), as well as a smooth muscle MYH (MYH11).
Sequence: A synthetic peptide corresponding to amino acid residues at the C-terminus from mouse MYH4/MyHC-IIB. This sequence has 100% identity with rat and human MYH4, and has significant homology to MYH1, MYH2, and MYH8.
Specificity: The peptide is specifically recognized by anti-MYH4/MyHC-IIB (C-terminus) antibody (MP4541) in ELISA, and has been shown to block the reactivity of MP4541 during Western blot. In addition, the peptide is recommended for use in blocking MP4541 reactivity in immunocytochemistry.
Buffer/Storage:
Blocking Peptide is supplied in 50µl phosphate-buffered saline and 0.05% sodium azide. Store at –20°C. Stable for 1 year.
Myosin is a highly conserved, ubiquitous protein found in all eukaryotic cells, where it provides the motor function for diverse movements such as cytokinesis, phagocytosis, and muscle contraction. All myosins contain an amino-terminal motor/head domain and a carboxy-terminal tail domain. The class II myosins, consist of the conventional two-headed myosins that form filaments and are composed of two myosin heavy chain (MYH) subunits and four myosin light chain subunits. There are 15 MYH genes identified as Class II myosins and these include six skeletal muscle MYHs (MYH1, MYH2, MYH3, MYH4, MYH8, MYH13), three cardiac MYHs (MYH6, MYH7, MYH7B) and two non-muscle MYHs (MYH9, MYH10), as well as a smooth muscle MYH (MYH11).
Sequence: A synthetic peptide corresponding to amino acid residues at the C-terminus from mouse MYH4/MyHC-IIB. This sequence has 100% identity with rat and human MYH4, and has significant homology to MYH1, MYH2, and MYH8.
Specificity: The peptide is specifically recognized by anti-MYH4/MyHC-IIB (C-terminus) antibody (MP4541) in ELISA, and has been shown to block the reactivity of MP4541 during Western blot. In addition, the peptide is recommended for use in blocking MP4541 reactivity in immunocytochemistry.
Buffer/Storage:
Blocking Peptide is supplied in 50µl phosphate-buffered saline and 0.05% sodium azide. Store at –20°C. Stable for 1 year.
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