MYD88 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP51372
Background:
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Other Names:
Myeloid differentiation primary response protein MyD88, MYD88
Antigen Type: synthetic peptide
Antigen Type: MYD88 (HGNC:7562)
Gene ID: 4615
Primary Accession: Q99836
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Other Names:
Myeloid differentiation primary response protein MyD88, MYD88
Antigen Type: synthetic peptide
Antigen Type: MYD88 (HGNC:7562)
Gene ID: 4615
Primary Accession: Q99836
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