Myosin Light Chain 2 monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO14275
Catalog Number: AC-ABO14275
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IP
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IP
Datasheet
Request Information
Description: Anti-Myosin Light Chain 2 Rabbit Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)..
Other Names: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, Ventricular myosin light chain 2, MYL2 (HGNC:7583)
Clone Name(s):
Clone: FHO-13
Subcellular Localization: Cytoplasm, myofibril, sarcomere, A band.
Gene ID: 4633
Immunogen: A synthesized peptide derived from human Myosin Light Chain 2
Calculated MW: 18789
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)..
Other Names: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, Ventricular myosin light chain 2, MYL2 (HGNC:7583)
Clone Name(s):
Clone: FHO-13
Subcellular Localization: Cytoplasm, myofibril, sarcomere, A band.
Gene ID: 4633
Immunogen: A synthesized peptide derived from human Myosin Light Chain 2
Calculated MW: 18789
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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