MYSM1 Polyclonal Antibody

Background:
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
2A-DUB, 2ADUB, Histone H2A deubiquitinase, Histone H2A deubiquitinase MYSM1, KIAA1915, Myb like SWIRM and MPN domains 1, Myb like, SWIRM and MPN domain containing protein, Myb like, SWIRM and MPN domains 1, Myb-like, Myb-like, SWIRM and MPN domains 1, MYSM 1, mysm1, MYSM1 Myb-like, SWIRM and MPN domains 1, MYSM1, RP4-592A1.1, SWIRM and MPN domain-containing protein 1

Immunogen: Synthetic peptide of human MYSM1

Swissprot: Q5VVJ2
Gene Accession: NP_001078956

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-161894/sc-161895