Na+ CP type IIβ rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015],function:Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR.,tissue specificity:Brain specific.,

Synonyms: SCN2B, Sodium channel subunit beta-2

Gene Name: SCN2B

Gene ID: 6327

SwissProt ID: O60939

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.