Na+/I- Symporter (NIS) polyclonal, anti-rat, pig, human

Quantity: 100 µl

Background:
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1

Synonyms:
NIS, TDH1

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic peptide from the C-terminus of rat NIS

Form: Serum containing 0.1% sodium azide

Specificity:
Suitable for studying the sensitivity of thyroid tumors to iodine treatment. Absorption with 50 – 100 ?g immunogen per ml diluted antiserum abolishes staining.

Reactivity: rat, pig, human

Applications: Immunohistochemistry. suitable for frozen sections

Working DIlution: 1:60 - 1:100 using FITC conjugates

Positive Control:
Frozen sections of rat thyroid

Storage: 2-8C for immediate use, or at -20C (aliquot)