NACA polyclonal, anti-human, mouse, rat

Background:
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants but the full length nature of some of these variants including those encoding very large proteins has not been determined. There are multiple pseudogenes of this gene on different chromosomes.

Synonyms: HSD48, NAC-alpha, NACA1, skNAC

Cellular Location: Cytoplasm Nucleus

Immunogen:
Recombinant protein of human NACA

Gene Symbol: NACA

Gene ID: 4666

Swiss prot: Q13765

Calculated MW: 205kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.