NAIP1/2/5 (clone Naipa-1), anti-mouse
€274.00
In stock
SKU
ARP-23-B0045
Catalog Number: 23-B0045
Size: 25 µg
Isotype: Mouse IgG2b kappa
Size: 25 µg
Isotype: Mouse IgG2b kappa
Decription:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Synonyms: Neuronal Apoptosis Inhibitory Protein 1, 2, 5, Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e, Birc 1a, 1b, 1e
Clone: Naipa-1
Isotype: Mouse IgG2b kappa
Immunogen: Recombinant mouse NAIP5 (BIR2 domain/aa 159-227).
Reactivity: mouse
Specificity: Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Western Blot: (1?g/ml)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Synonyms: Neuronal Apoptosis Inhibitory Protein 1, 2, 5, Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e, Birc 1a, 1b, 1e
Clone: Naipa-1
Isotype: Mouse IgG2b kappa
Immunogen: Recombinant mouse NAIP5 (BIR2 domain/aa 159-227).
Reactivity: mouse
Specificity: Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Western Blot: (1?g/ml)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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