NALP10 polyclonal, anti-human
€484.00
In stock
SKU
254349
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1beta, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1beta processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
Alternate Names: NALP10, NACHT, LRR and PYD domains-containing protein 10, NLRP10, NOD8, CLR11.1, PAN5, PYNOD
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_789791
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP10.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1beta, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1beta processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
Alternate Names: NALP10, NACHT, LRR and PYD domains-containing protein 10, NLRP10, NOD8, CLR11.1, PAN5, PYNOD
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_789791
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP10.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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