NALP12 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254351
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappaB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Alternate Names: NALP12, NACHT, LRR and PYD domains-containing protein 12, NLRP12, FCAS2, CLR19.3, PAN6, PYPAF7, RNO, RNO2, Monarch-1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_653288
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP12.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappaB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Alternate Names: NALP12, NACHT, LRR and PYD domains-containing protein 12, NLRP12, FCAS2, CLR19.3, PAN6, PYPAF7, RNO, RNO2, Monarch-1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_653288
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NALP12.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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